When Standard Antidepressants Haven't Worked

You have tried more than one antidepressant. Maybe it helped a little and then stopped. Maybe it never touched how you actually feel. If depression is still running your life after real attempts to treat it, you may be dealing with treatmentresistant depression — and it calls for a different approach than trying medication number four the same way you tried number one.

Same provider every visit · No referral needed

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Does any of this sound familiar?

You’ve tried two or more antidepressants without meaningful, lasting relief.
A medication helped at first, then stopped working.
Side effects made past medications hard to stay on.
You feel like your provider was guessing rather than building a real plan.
You’ve wondered whether something like Spravato might actually be the answer, but no one brought it up.

Treatment-Resistant Depression Evaluation

Full Medication History Review
A clear-eyed look at every antidepressant trial, including dose, duration, and response.

Augmentation Strategy
Sometimes the best approach is adjusting or combining current medications rather than starting over.

Spravato Eligibility Screening
If you meet criteria, we’ll walk through whether Spravato (esketamine) may be a fit for you.

Coordinated Care
We work alongside your therapist when therapy is part of your care.

You’re not out of options.

An estimated one in three patients with major depressive disorder does not get adequate
relief from standard antidepressants. That’s not a reflection of how hard you’ve tried — it’s a
real clinical category with real treatment options, including some that work through a
completely different mechanism than the pills you’ve already tried.

Frequently Asked Questions

How many antidepressants do I need to have tried?

Two or more adequate trials at proper dose and duration is the general benchmark, but bring your full history
and we’ll assess it together.

Is Spravato guaranteed once I'm evaluated here?

No — eligibility depends on your diagnosis, treatment history, and insurance. Evaluation is the first step, not a guarantee.

What if I've never tried an antidepressant at all?

This page is specifically for patients who’ve already tried treatment without adequate relief. If you haven’t
started treatment yet, book under Psychiatric Medication Management instead.

What Patients Say About Ample Grace Psychiatry

      GOOD  
   Based on 61 reviews 
    
 
 
 
   
 
 
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   montes bryan 
 
 
 
 Trustindex verifies that the original source of the review is Google. Professional, Kind, and Truly Caring Dr. Osadolor is one of the most compassionate providers I’ve ever worked with. She doesn’t rush appointments and really gets to the heart of what’s going on. I came in feeling burnt out and anxious, and left feeling hopeful and heard. Ample Grace Psychiatry lives up to its name—this practice is full of grace and healing.
  
 
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   Gezelle Gonowon 
 
 
 
 Trustindex verifies that the original source of the review is Google. ⭐️⭐️⭐️⭐️⭐️ Exceptional Mental Health Care From the first appointment, I knew I was in good hands. The staff at Ample Grace Psychiatry are welcoming, and Dr. Osadolor is thorough, knowledgeable, and gentle in her approach. She helped me explore both medication and holistic options, and always respects my preferences. It’s rare to find such a balanced and integrative psychiatrist!
  
 
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   leandro sabido 
 
 
 
 Trustindex verifies that the original source of the review is Google. Supportive and Safe Environment Dr. Osadolor creates such a safe space to talk about even the most difficult topics. I felt understood and never judged. Her approach is trauma-informed and empowering. She’s helped me set boundaries, manage anxiety, and feel stronger emotionally. I truly believe she’s changing lives with her work at Ample Grace.
  
 
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   richard sabidalas 
 
 
 
 Trustindex verifies that the original source of the review is Google. Outstanding for Busy Professionals As a high-achieving professional dealing with stress and burnout, I finally feel like I’ve found the right provider. Dr. Osadolor gets it—she offers practical strategies, deep insight, and incredible support. I’ve recommended Ample Grace Psychiatry to friends and coworkers. If you're overwhelmed and ready to feel better, this is where you want to be.
  
 
      Posted on Google  
   
   Jan efren Salting 
 
 
 
 Trustindex verifies that the original source of the review is Google. Ample Grace Psychiatry has been a game-changer for me! From the very first appointment, I felt truly heard and understood. The provider took the time to thoroughly assess my ADHD symptoms and worked with me to create a treatment plan that actually fits my lifestyle. Since starting treatment, I've noticed a huge improvement in my focus, productivity, and overall well-being. If you're struggling with ADHD and looking for compassionate, knowledgeable care, I highly recommend Ample Grace Psychiatry!

Partnering With Minnesota Providers

We work alongside therapists, primary care providers, OB-GYNs, and psychologists across Minnesota. If you’re a provider looking to refer a patient, we make the process simple.

Ready to get started?

New patient appointments are available this week. No referral needed. The same provider at every visit.

Questions? Call 800-223-4914

AMPLE

GRACE PSYCHIATRY

Ample Grace Psychiatry provides thoughtful, personalized psychiatric care through secure telehealth across Minnesota. Founded by Dr. Uhunoma Osadolor, DNP, PMHNP-BC, the practice is built around consistent care, thorough evaluation, and a genuine understanding of each patient’s full story.

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©2026 Ample Grace Psychiatry — All Rights Reserved
Telehealth services available to patients physically located in states where Dr. Osadolor holds an active license. This website is for informational purposes only and does not constitute medical advice.

Specialized Care

ADHD & Attention

Mood & Depression

Anxiety & Trauma

Psychiatric Care