When Standard Antidepressants Haven't Worked

You have tried more than one antidepressant. Maybe it helped a little and then stopped. Maybe it never touched how you actually feel. If depression is still running your life after real attempts to treat it, you may be dealing with treatmentresistant depression — and it calls for a different approach than trying medication number four the same way you tried number one.

Same provider every visit · No referral needed

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Does any of this sound familiar?

You’ve tried two or more antidepressants without meaningful, lasting relief.
A medication helped at first, then stopped working.
Side effects made past medications hard to stay on.
You feel like your provider was guessing rather than building a real plan.
You’ve wondered whether something like Spravato might actually be the answer, but no one brought it up.

Treatment-Resistant Depression Evaluation

Full Medication History Review
A clear-eyed look at every antidepressant trial, including dose, duration, and response.

Augmentation Strategy
Sometimes the best approach is adjusting or combining current medications rather than starting over.

Spravato Eligibility Screening
If you meet criteria, we’ll walk through whether Spravato (esketamine) may be a fit for you.

Coordinated Care
We work alongside your therapist when therapy is part of your care.

You’re not out of options.

An estimated one in three patients with major depressive disorder does not get adequate
relief from standard antidepressants. That’s not a reflection of how hard you’ve tried — it’s a
real clinical category with real treatment options, including some that work through a
completely different mechanism than the pills you’ve already tried.

Frequently Asked Questions

How many antidepressants do I need to have tried?

Two or more adequate trials at proper dose and duration is the general benchmark, but bring your full history
and we’ll assess it together.

Is Spravato guaranteed once I'm evaluated here?

No — eligibility depends on your diagnosis, treatment history, and insurance. Evaluation is the first step, not a guarantee.

What if I've never tried an antidepressant at all?

This page is specifically for patients who’ve already tried treatment without adequate relief. If you haven’t
started treatment yet, book under Psychiatric Medication Management instead.

What Patients Say About Ample Grace Psychiatry

Partnering With Minnesota Providers

We work alongside therapists, primary care providers, OB-GYNs, and psychologists across Minnesota. If you’re a provider looking to refer a patient, we make the process simple.

Ready to get started?

New patient appointments are available this week. No referral needed. The same provider at every visit.

Questions? Call 800-223-4914

AMPLE

GRACE PSYCHIATRY

Ample Grace Psychiatry provides thoughtful, personalized psychiatric care through secure telehealth across Minnesota. Founded by Dr. Uhunoma Osadolor, DNP, PMHNP-BC, the practice is built around consistent care, thorough evaluation, and a genuine understanding of each patient’s full story.

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Telehealth services available to patients physically located in states where Dr. Osadolor holds an active license. This website is for informational purposes only and does not constitute medical advice.

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